Microfluidic Systems for the Skin

Northwestern University

Dr. Roozbeh Ghaffari, Co-Founder, Chief Executive Officer Epicore Biosystems, Inc.

There is a clear need for objective and quantitative methods to monitor physiological and cognitive performance in response to fatigue, dehydration, and acute and chronic injuries, such as concussions, stroke, heart failure, and kidney disease.

We have developed a proprietary wearable microfluidics platform that is ‘skin-like’, low-cost, and capable of analyzing small volumes of sweat directly from human skin pores. This novel device platform monitors sweat biochemistry, including total sweat loss, pH, lactate, sodium, chloride, cortisol, and glucose concentrations in combination with electrophysiological activity, in real time. The unique physiological datasets captured by the wearable microfluidics device could then be transmitted to care providers using a smartphone, and longitudinally analyzed to monitor for daily, weekly and monthly trends in physical restoration, rehabilitation, and performance.

Development of non-invasive, and yet, imperceptible technologies that identify novel digital biomarkers directly tied to physiological state and changes therein represents a grand challenge for the future of sports, rehabilitation, and disease management.

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